Respiratory infections are caused by an array of viruses, and limited information is available about viral coexistence, comparative\nsymptoms, and the burden of illness. This retrospective cohort study aimed to determine the etiological agents responsible for\nrespiratory tract infections by Anyplex II RV16 detection kit (RV16, Seegene), involving 2266 pediatric patients with respiratory\ninfections admitted to the Department of Pediatrics at King Abdul-Aziz Medical City, Ministry of National Guard, Riyadh, from\nJuly 2014 to June 2015. The most frequent respiratory infections were recorded in the 1 to 5 year age group (44.7%). Rhinovirus\n(32.5%), Adenovirus (16.9%), and Respiratory syncytial virus (RSV) B (10.4%) were most common. In single viral infections,\nRhinovirus (41.2%),Metapneumovirus (15.3%), and Bocavirus (13.7%) were most frequent. Inmultiple viral infections, Rhinovirus\n(36.7%), Adenovirus (35.2%), Bocavirus (11.2), RSV B (7.8%), and RSV A (6.7%) were most frequent. No significant difference\nwas observed in clinical presentations; however, rhinorrhea and hypodynamia were significantly associated with viral respiratory\ninfections. Most respiratory viral pathogens peaked during December, January, March, and April. Rhinovirus, Adenovirus, and\nBocavirus circulations were detected throughout the year. Winter peaks were recorded for Rhinovirus, RSV B, Adenovirus, and\nRSV A, whereas the Metapneumovirus, and the Bocavirus peaked in March and April. These findings enhance understanding of\nviral etiology and distribution to improve respiratory infection management and treatment.
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